General
Preferred name
PD007523
Synonyms
ARL 17477 dihydrochloride ()
N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide ()
ARL 17477 ()
P&D ID
PD007523
CAS
866914-87-6
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling
(Tocris Bioactive Compound Library)
DESCRIPTION
The hydrochloride salt form of ARL 17477, which has been found to be a nitric oxide synthase (NOS) inhibitor and could induce apoptosis/cell death in leukemia cells.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
DrugBank
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
369.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
5.17
TPSA
47.91
Fraction CSP3
0.15
Chiral centers
0.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
nNOS
MOA
Inhibitor
Pathway
Immunology/Inflammation
Target
NO Synthase
Source data
