General
Preferred name
THYMINE
Synonyms
5-methyluracil ()
Thymine-d4 ()
Thymine-13C5,15N2 ()
P&D ID
PD007511
CAS
2792-47-4
3059-73-2
65-71-4
156054-85-2
2483830-13-1
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Thymine, one of the four bases of DNA, is a substrate for rat liver dihydropyrimidine dehydrogenase (DPD), with a Km value of 2.2 ¦ÌM, Ki of 24 ¦ÌM (using 5-FU as the DPD substrate), and a specific activity of 0.68 nmol/min/mg[1].
PRICE
29
DESCRIPTION
Thymine is one of the four bases of DNA and is able to act as a target for 5-fluorouracil in animal cancer models with Km=2.3 ??M.
DESCRIPTION
Thymine is one of the four nucleobases in the nucleic acid of DNA. It inhibits dihydropyrimidine dehydrogenase [NADP(+)].
(Enamine Bioactive Compounds)
DESCRIPTION
Thymine is one of the four bases of DNA and is able to act as a target for 5-fluorouracil in animal cancer models with Km=2.3 μM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
126.04
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.63
TPSA
65.72
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
DNA/RNA Synthesis
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data
