General
Preferred name
DAZOXIBEN
Synonyms
Ah-p 719 ()
UK-37248 ()
DAZOXIBEN HYDROCHLORIDE ()
Dazoxiben (hydrochloride) ()
UK 37248 ()
Dazoxiben HCl ()
Dazoxibene ()
UK-37,248-01 ()
UK-37248-01 ()
P&D ID
PD007429
CAS
103735-00-8
78218-09-4
74226-22-5
Tags
available
drug candidate
Drug Status
investigational
experimental
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dazoxiben hydrochloride is a potent and orally active thromboxane (TX) synthase inhibitor[1].
PRICE
77
DESCRIPTION
Dazoxiben (UK-37248) is a potent inhibitor of thromboxane (TX) synthase
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
15
ChEMBL Drugs
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
232.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
1.66
TPSA
64.35
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Thromboxane (TX) synthase
TBXAS1
P450 (e.g. CYP17),PGES,Prostaglandin Receptor
Member status
member
MOA
Thromboxane Synthase Inhibitors
thromboxane synthase inhibitor
Pathway
GPCR/G protein
Immunology/Inflammation
Source data
