General
Preferred name
zebularine
Synonyms
NSC309132 ()
4-Deoxyuridine ()
P&D ID
PD007414
CAS
3690-10-6
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
31
DESCRIPTION
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 ??M, in a cell-free assay).
DESCRIPTION
Inhibitor of protein phosphatase 2C (PP2C)
(Tocris Bioactive Compound Library)
DESCRIPTION
DNA methyltransferase and cytidine deaminase inhibitor
(Tocriscreen Total)
DESCRIPTION
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Axon Medchem Screening Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
Guide to Pharmacology
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
228.07
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
-2.15
TPSA
104.81
Fraction CSP3
0.56
Chiral centers
4.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
DNA Methyltransferases
MOA
Inhibitor
DNA Methyltransferase (DNMT) Inhibitors
Cytidine Deaminase (CDA) Inhibitors
DNA Methyltransferase inhibitor
Member status
member
Target
CDA, DNMT1
DNA MTase inhibitor
Cytidine deaminase
DNA methyltransferase (DNMT)
Pathway
Autophagy
Chromatin/Epigenetic
Source data
