General
Preferred name
BATIMASTAT
Synonyms
BB-94 sodium salt ()
BB94 ()
Batimastat (BB-94) ()
Batimastat (sodium salt) ()
BB-94 (sodium salt) ()
Batimastat sodium salt ()
BB-94 ()
P&D ID
PD007159
CAS
130370-60-4
130464-84-5
Tags
available
drug candidate
Drug indication
Idiopathic pulmonary fibrosis
Drug Status
experimental
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Batimastat (BB-94) is a broad-spectrum matrix metalloprotease (MMP) inhibitor. It inhibits MMPs by binding the zinc ion in the active site of the enzymes.
(GtoPdb)
DESCRIPTION
Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.
PRICE
172
DESCRIPTION
GAPDH inhibitor; neuroprotective
(Tocris Bioactive Compound Library)
DESCRIPTION
Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Batimastat sodium salt (BB-94) is a potent, broad spectrum matrix metalloprotease (MMPs) inhibitor with IC50s of 3/4/20/6/4 nM for MMP-1/2/3/7/9 respectively.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
477.18
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
12
Ring Count
2
Aromatic Ring Count
2
cLogP
3.1
TPSA
107.53
Fraction CSP3
0.43
Chiral centers
3.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
MMP
MMP-1
MMP-2
MMP-3
MMP-7
MMP-9
ADAM28, ADAMTS5, MMP12, MMP16, MMP2, MMP8
MMP2
Primary Target
Matrix Metalloproteases
MOA
Inhibitor
Angiogenesis Inhibitors
Matrix Metalloproteinase Inhibitors
"Angiogenesis Inhibitors
Matrix Metalloproteinase Inhibitors"
matrix metalloprotease inhibitor
Member status
member
Pathway
Metabolic Enzyme/Protease
Proteases/Proteasome
Source data
