General
Preferred name
PD007101
Synonyms
PNU112455A ()
CDK2/5 inhibitor ()
PNU 112455A HCL ()
PNU112455A (hydrochloride) ()
PNU112455A hydrochloride ()
4-[(6-Amino-4-Pyrimidinyl)Amino]Benzenesulfonamide ()
PNU 112455A ()
P&D ID
PD007101
CAS
21886-12-4
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 ¦ÌM, respectively[1].
PRICE
76
DESCRIPTION
PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 ??M, respectively.
DESCRIPTION
PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
265.06
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
0.45
TPSA
123.99
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CDK
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
Source data
