General
Preferred name
DEXPROPRANOLOL
Synonyms
DEXPROPRANOLOL HYDROCHLORIDE [R(+)] ()
(R)-(+)-Propranolol hydrochloride ()
DEXPROPRANOLOL HYDROCHLORIDE ()
(R)-(+)-Propranolol ()
(R)-Propranolol hydrochloride ()
(R)-Propranolol (hydrochloride) ()
AY-20,694 ()
NSC-757295 ()
I.C.I. 47,319 ()
ICI-47319 ()
AY-20694 ()
Propranolol hydrochloride, (r)- ()
Dexpropranolol hcl ()
(+)-propranolol ()
Propranolol, (r)- ()
P&D ID
PD007086
CAS
13071-11-9
5051-22-9
Tags
available
drug candidate
Drug Status
investigational
experimental
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (R)-Propranolol hydrochloride is a less active enantiomer of the?¦Â-adrenoceptor antagonist?propranolol (HY-B0573). Propranolol is a nonselective ¦Â-adrenergic receptor (¦ÂAR) antagonist, has high affinity for the ¦Â1AR and ¦Â2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1].
PRICE 29
DESCRIPTION (R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (??-adrenoceptor) antagonist propranolol. Propranolol is a nonselective ??-adrenergic receptor (??AR) antagonist with a high affinity for ??1AR and ??2AR with Ki values of 1.8 nM and 0.8 nM, respectively.
DESCRIPTION A component of the approved drug propranolol. Propranolol is a racemic mixture of two enantiomers (+)-propranolol, and (-)-propranolol. (GtoPdb)
DESCRIPTION β antagonist. Less active enantiomer of propranolol (Cat. No. 0624) (Tocriscreen Total)
DESCRIPTION Peripherally acting mu agonist; Ca2+ channel blocker (Tocris Bioactive Compound Library)
DESCRIPTION (R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. (TargetMol Bioactive Compound Library)
Compound Sets
14
ChEMBL Drugs
CHEMBL1358662
CHEMBL275742
Concise Guide to Pharmacology 2017/18
7596
Concise Guide to Pharmacology 2019/20
7596
Concise Guide to Pharmacology 2021/22
7596
Concise Guide to Pharmacology 2023/24
7596
Drug Repurposing Hub
DrugBank
DB03322
Guide to Pharmacology
7596
MedChem Express Bioactive Compound Library
HY-A0295
Prestwick Chemical Library
TargetMol Bioactive Compound Library
T20898
The Spectrum Collection
Tocris Bioactive Compound Library
0835
Tocriscreen Total
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
259.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.58
TPSA
41.49
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
β-adrenoceptor
ADRB2, ADRB3
Adrenergic Receptor
Primary Target
Non-selective Adrenergic ? Receptors
MOA
Antagonist
Adrenergic Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data