General
Preferred name
PF-00356231
Synonyms
PF 00356231 ()
PF-00356231 (hydrochloride) ()
PF-00356231 hydrochloride ()
P&D ID
PD007047
CAS
766536-21-4
820223-77-6
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 ¦ÌM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 ¦ÌM, respectively[1].
PRICE 299
DESCRIPTION PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 ??M.
DESCRIPTION PF 00356231 is a MMP-12 inhibitor, and at high concentrations it also inhibits other MMPs. (BOC Sciences Bioactive Compounds)
DESCRIPTION PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM. (TargetMol Bioactive Compound Library)
Compound Sets
7
Axon Medchem Screening Library
1181
BOC Sciences Bioactive Compounds
pf-00356231-cas-766536-21-4-item-54508
DrugBank
DB03367
DrugMAP
DMV43NF
MedChem Express Bioactive Compound Library
HY-114091
TargetMol Bioactive Compound Library
T12414
ZINC Tool Compounds
ZINC000006744035
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
428.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
4
cLogP
5.42
TPSA
79.29
Fraction CSP3
0.08
Chiral centers
1.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
MMP
MMP-12
MMP-13
MMP-3
MMP-8
MMP-9
MMP inhibitor
Pathway
Metabolic Enzyme/Protease
Proteases/Proteasome
Source data