General
Preferred name
MDL-29951
Synonyms
2-CARBOXY-4,6-DICHLORO-(1H)-INDOLE-3-PROPANOIC ACID ()
MDL 29951 ()
P&D ID
PD006907
CAS
101861-63-6
130798-51-5
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 ¦ÌM for [3H]glycine binding in vitro and in vivo.
PRICE 123
DESCRIPTION MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo. (BOC Sciences Bioactive Compounds)
DESCRIPTION MDL-29951 is a novel glycine antagonist for NMDA receptor activation. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
12
AdooQ Bioactive Compound Library
A13729
BOC Sciences Bioactive Compounds
mdl-29951-cas-130798-51-5-item-84-462696
Cayman Chemical Bioactives
16266
Drug Repurposing Hub
DrugBank
DB04175
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100162
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL31344
MedChem Express Bioactive Compound Library
HY-16312
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T1897
ZINC Tool Compounds
ZINC000000004763
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
300.99
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.19
TPSA
90.39
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Member status
member
MOA
Fructose-1,6-Bisphosphatase Inhibitors
NMDA Glycine-Site Antagonists
GPR17 gene modulator
glutamate receptor antagonist
Target
FBP1
iGluR
NMDA Receptor
Source data