General
Preferred name
METHYLMALONIC ACID
Synonyms
NSC 25201 ()
MMA ()
Isosuccinic acid ()
Methylpropanedioic acid ()
Methylmalonate ()
Methylmalonic acid, Isosuccinic Acid, NSC 25201, MMA ()
Methylmalonic Acid-d3 ()
P&D ID
PD006899
CAS
516-05-2
42522-59-8
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Succinate receptor agonist
(GtoPdb)
DESCRIPTION
Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.
PRICE
29
DESCRIPTION
Transglutaminase inhibitor; neuroprotective
(Tocris Bioactive Compound Library)
DESCRIPTION
Methylmalonate, a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA), binds with coenzyme A to form methylmalonyl-CoA. It is a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models and induces apoptotic cell death in striatal neurons.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Methylmalonic acid is an indicator of vitamin B-12 deficiency in cancer patients.Methylmalonic acid is a competitive succinate dehydrogenase inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
DrugBank
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
118.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.21
TPSA
74.6
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
0.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
SDH
Endogenous Metabolite
Primary Target
Other Dehydrogenases
MOA
Inhibitor
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
