General
Preferred name
NORVALINE
Synonyms
L-Norvaline ()
L-Norvaline ()
P&D ID
PD006845
CAS
6600-40-4
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
L-Norvaline is an endogenous metabolite. It inhibits human enzyme dimethylarginine dimethylaminohydrolase-1 (DDAH1) with IC50 = 1.42 µM, it also inhibits arginase.
(Enamine Bioactive Compounds)
DESCRIPTION
L-Norvaline is an arginase inhibitor and a non-protein branched-chain amino acid. L-Norvaline has previously been reported as a natural component of the antifungal peptide of Bacillus subtilis. L-Norvaline and other modified branched-chain amino acids have received attention in recent studies because they appear to be incorporated into some recombinant proteins found in E. coli.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
117.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
0.2
TPSA
63.32
Fraction CSP3
0.8
Chiral centers
1.0
Largest ring
0.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Arginase
Amyloid-β
TNF Receptor
Pathway
Immunology/Inflammation
Metabolism
Apoptosis
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
