General
Preferred name
SPERMIDINE
Synonyms
SPERMIDINE TRIHYDROCHLORIDE ()
Spermidine hydrochloride ()
4-Azaoctamethylenediamine trihydrochloride ()
N-(3-Aminopropyl)-1,4-diaminobutane ()
N-(4-Aminobutyl)-1,3-diaminopropane ()
Spermidine (hydrochloride) ()
Spermidine-d6 ()
P&D ID
PD006808
CAS
334-50-9
124-20-9
1122077-27-3
2514812-10-1
Tags
available
drug candidate
Drug indication
Hypertension
Plaque psoriasis
Rheumatoid arthritis
Drug Status
experimental
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
PRICE 29
DESCRIPTION Binds to the polyamine modulatory site of the NMDA glutamate receptor (LOPAC library)
DESCRIPTION Agonist at polyamine site (Tocriscreen Total)
DESCRIPTION Spermidine trihydrochloride is a polyamine that binds to NMDA receptor. Spermidine has been described as an agonist for its ability to enhance the binding of [3H]-MK801. It also acts as a NOS1 inhibitor. (BOC Sciences Bioactive Compounds)
DESCRIPTION Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride), a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA). (TargetMol Bioactive Compound Library)
DESCRIPTION Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
21
BOC Sciences Bioactive Compounds
spermidine-trihydrochloride-cas-334-50-9-item-17260
Cayman Chemical Bioactives
14918
34697
ChEMBL Drugs
CHEMBL19612
Concise Guide to Pharmacology 2017/18
2390
Concise Guide to Pharmacology 2019/20
2390
Concise Guide to Pharmacology 2021/22
2390
Concise Guide to Pharmacology 2023/24
2390
Drug Repurposing Hub
DrugBank
DB03566
DrugMAP
DMVJNFI
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101024
Guide to Pharmacology
2390
Ki Database
Spermidine
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1776A
HY-B1776
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
spermidine-trihydrochloride
spermidine
TargetMol Bioactive Compound Library
T5080
T4893
The Spectrum Collection
Tocriscreen Total
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
145.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.34
TPSA
64.07
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA-Polyamine
Target
Endogenous Metabolite
Human Endogenous Metabolite
KCNJ4, TXNRD1
Autophagy,NMDAR
NMDA Receptor
MOA
NMDAR
Autophagy
Protein tyrosine phophatase N-like stimulator
Drugs Acting on NMDA Receptors
glutamate receptor modulator
Member status
member
Pathway
Neuroscience
Metabolism
Metabolic Enzyme/Protease
Source data