General
Preferred name
SPERMIDINE
Synonyms
SPERMIDINE TRIHYDROCHLORIDE ()
N-(4-Aminobutyl)-1,3-diaminopropane ()
N-(3-Aminopropyl)-1,4-diaminobutane ()
Spermidine hydrochloride ()
Spermidine (hydrochloride) ()
4-Azaoctamethylenediamine trihydrochloride ()
Spermidine-d6 ()
P&D ID
PD006808
CAS
334-50-9
124-20-9
1122077-27-3
2514812-10-1
Tags
drug candidate
natural product
available
Drug indication
Plaque psoriasis
Rheumatoid arthritis
Drug Status
experimental
investigational
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Binds to the polyamine modulatory site of the NMDA glutamate receptor
(LOPAC library)
DESCRIPTION
Agonist at polyamine site
(Tocriscreen Total)
DESCRIPTION
Spermidine trihydrochloride is a polyamine that binds to NMDA receptor. Spermidine has been described as an agonist for its ability to enhance the binding of [3H]-MK801. It also acts as a NOS1 inhibitor.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
0
Compound Sets
21
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Molecular Weight
145.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.34
TPSA
64.07
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA-Polyamine
Pathway
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Target
Human Endogenous Metabolite
NMDA Receptor
KCNJ4, TXNRD1
Autophagy,NMDAR
MOA
NMDAR
Autophagy
Endogenous Metabolite
Protein tyrosine phophatase N-like stimulator
Drugs Acting on NMDA Receptors
glutamate receptor modulator
Member status
member
Source data
