General
Preferred name
(R)-Rolipram
Synonyms
(R)-(-)-Rolipram ()
(-)-ROLIPRAM ()
P&D ID
PD006775
CAS
85416-75-7
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
PRICE 65
DESCRIPTION Potent, selective JAK3 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) (Tocriscreen Total)
DESCRIPTION (R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor. It is 2.5-fold more potent than (+)-rolipram in inhibiting membrane-bound PDE 4. (BOC Sciences Bioactive Compounds)
DESCRIPTION PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) (Tocriscreen Plus)
DESCRIPTION (R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
13
Axon Medchem Screening Library
1229
BOC Sciences Bioactive Compounds
r-rolipram-cas-85416-75-7-item-84-209158
Cayman Chemical Bioactives
31111
Drug Repurposing Hub
DrugBank
DB04149
DrugMAP
DM95Z4Q
EUbOPEN Chemogenomics Library
EUB0002474
MedChem Express Bioactive Compound Library
HY-16900A
TargetMol Bioactive Compound Library
T13448
Tocris Bioactive Compound Library
1349
Tocriscreen Plus
1349
Tocriscreen Total
ZINC Tool Compounds
ZINC000000004982
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
275.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
2.62
TPSA
47.56
Fraction CSP3
0.56
Chiral centers
1.0
Largest ring
6.0
QED
0.92
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Primary Target
Phosphodiesterases
MOA
Inhibitor
phosphodiesterase inhibitor
Target
PDE4A, PDE4B, PDE4C, PDE4D, PDE5A
PDE4 inhibitor
Phosphodiesterase (PDE)
Pathway
Metabolic Enzyme/Protease
DNA Damage/DNA Repair
PI3K/Akt/mTOR signaling
Recommended Cell Concentration
None
Source data