General
Preferred name
DIMINAZENE
Synonyms
DIMINAZENE ACETURATE ()
DIZE ()
DIMINAZENE DIACETURATE ()
Diminazene (aceturate) ()
Diminazene (diaceturate) ()
4,4'-(diazoamino)benzamidine ()
Diminazen ()
Diminazeno ()
P&D ID
PD006773
CAS
536-71-0
908-54-3
31384-83-5
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
investigational
Max Phase
2.0
Probe info
Probe type
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties[1][2][3].
PRICE
29
DESCRIPTION
Administered as diminazene aceturate (CID 5284544), this is a is a trypanocidal agent that has been used in veterinary practice since 1955.
(GtoPdb)
DESCRIPTION
Selective TRPM4 blocker
(Tocris Bioactive Compound Library)
DESCRIPTION
Diminazene is a trypanocidal agent.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
7
Compound Sets
18
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
281.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
2.37
TPSA
136.49
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.25
Structural alerts
1
azo_A(324)
[#7;!R]=[#7]
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Target
Angiotensin-converting Enzyme (ACE)
Parasite
Peroxiredoxin-5
QacR
Trypsin-1
AOC1, PRDX5, PRSS1
ACE,Parasite
Primary Target
Acid-Sensing Ion Channels
MOA
Serine Protease
Blocker
angiotensin converting enzyme activator
Pathway
Microbiology/virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Source data
