General
Preferred name
CKI-7
Synonyms
CKI 7 dihydrochloride ()
CKI 7 2HCl ()
CKI-7 dihydrochloride ()
CKI7 2HCl ()
CKI7 dihydrochloride ()
CKI-7 2HCl ()
CKI-7 (free base) ()
N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide ()
CKI-7 (hydrochloride) ()
P&D ID
PD006697
CAS
1177141-67-1
120615-25-0
Tags
available
drug candidate
Drug indication
Mood disorder
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 278
DESCRIPTION CKI-7 is a potent, ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 ??M; Ki: 8.5 ??M) and a selective Cdc7 kinase inhibitor. It also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.
DESCRIPTION CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 ¦ÌM and a Ki of 8.5 ¦ÌM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases[1][2][3][4].
DESCRIPTION High affinity MDM2 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION CK1 inhibitor (Tocriscreen Plus)
DESCRIPTION CKI 7 is a CK1 inhibitor, and also inhibits SGK, S6K1 and MSK1. In combination with SB 431542, CKI 7 was shown to induce retinal cell differentiation from human ESCs and iPSCs. (BOC Sciences Bioactive Compounds)
DESCRIPTION CKI-7 is a potent, ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. It also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1. (TargetMol Bioactive Compound Library)
Compound Sets
10
Axon Medchem Screening Library
3279
BOC Sciences Bioactive Compounds
cki-7-dihydrochloride-cas-1177141-67-1-item-286191
Cayman Chemical Bioactives
28268
Drug Repurposing Hub
DrugBank
DB03693
DrugMAP
DMV0RFU
MedChem Express Bioactive Compound Library
HY-133028
TargetMol Bioactive Compound Library
T19913
Tocris Bioactive Compound Library
5329
Tocriscreen Plus
5329
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
285.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
1.13
TPSA
85.08
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Cdc7
CK1
MSK1
S6K1
SGK
CSNK1G2
CK1 inhibitor
Casein kinase
CDK
Ribosomal S6 Kinase (RSK)
Primary Target
Casein Kinase 1
MOA
Inhibitor
Casein Kinase inhibitor
Pathway
Cell Cycle/Checkpoint
Cytoskeletal Signaling
MAPK
Metabolism
PI3K/Akt/mTOR signaling
Stem Cells
Cell Cycle/DNA Damage
MAPK/ERK Pathway
Metabolic Enzyme/Protease
Stem Cell/Wnt
Source data