General
Preferred name
N-Phenylthiourea
Synonyms
PHENYLTHIOUREA ()
N-Phenylthiourea, PTU, Phenylthiocarbamide ()
1-PHENYL-2-THIOUREA ()
phenylthiocarbamide ()
1-Phenylthiourea ()
P&D ID
PD006696
CAS
103-85-5
Tags
available
drug candidate
natural product
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION N-Phenylthiourea (Phenylthiocarbamide) is a phenyl ring-containing organothiourea that acts as an EC 1.14.18.1 (tyrosinase) inhibitor, a diphenolase inhibitor, and a non-competitive inhibitor of the PvdP tyrosinase of Pseudomonas, which inhibits melanogenesis, and is able to be used in genetic taste testing.
DESCRIPTION Genetic variants of the TAS2R38 gene determine whether this compound is sensed as bitter-tasting or tasteless. (GtoPdb)
DESCRIPTION 1-phenylthiourea is a tyrosinase inhibitor. (Enamine Bioactive Compounds)
Cell lines
2
Organisms
0
Compound Sets
8
Cayman Chemical Bioactives
30855
Concise Guide to Pharmacology 2023/24
12496
DrugBank
DB03694
DrugMAP
DMM1IAU
Enamine Bioactive Compounds
EBC-03125
Guide to Pharmacology
12496
Selleckchem Bioactive Compound Library
1-phenyl-2-thiourea
ZINC Tool Compounds
ZINC000003875720
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
152.04
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
1.34
TPSA
38.05
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Tyrosinase
Source data