General
Preferred name
CLORGILINE
Synonyms
CLORGILINE HYDROCHLORIDE ()
CLORGYLINE HYDROCHLORIDE ()
CLORGYLINE ()
N-?Methyl-?N-?propargyl-?3-?(2,4-?dichlorophenoxy)?propylamine hydrochloride ()
M&B 9302 ()
Clorgyline HCl ()
Clorgyline (hydrochloride) ()
Clorgilina ()
M&B-9302 ()
P&D ID
PD006555
CAS
17780-75-5
17780-72-2
Tags
available
drug
Drug indication
Skin imperfections
Parkinson disease
Drug Status
approved
experimental
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A). Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3].
PRICE
33
DESCRIPTION
Clorgiline is an analogue of .
(GtoPdb)
DESCRIPTION
Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases[1].
PRICE
36
DESCRIPTION
Clorgyline is an antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.
DESCRIPTION
Selective MAO-A inhibitor
(LOPAC library)
DESCRIPTION
Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 µM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Clorgyline hydrochloride (Clorgiline hydrochloride), a white powder, is served as monoamine oxidase inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
23
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
271.05
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
3.33
TPSA
12.47
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
MAO-A
Pathway
Metabolism
Neuroscience
Neuronal Signaling
Target
MAOA
Monoamine Oxidase
MAO
MOA
monoamine oxidase inhibitor
Therapeutic Class
Antiparkinson Agents
Source data
