General
Preferred name
p-Coumaric Acid
Synonyms
para-coumaric acid ()
4-Hydroxycinnamic acid ()
trans-4-Hydroxycinnamic acid ()
Trans-p-Coumaric acid ()
4-Coumaric acid ()
p-Hydroxycinnamic acid ()
3-(4-hydroxyphenyl)acrylic acid ()
4-Hydroxycinnamic acid, P-Hydroxycinnamic acid, 4-Coumaric acid, Trans-p-Coumaric acid, para-Coumaric Acid ()
p-Hydroxy-cinnamic acid ()
COUMARIC ACID ()
P&D ID
PD006508
CAS
501-98-4
7400-08-0
50940-26-6
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities[1][2][3][4].
DESCRIPTION
p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 ¦ÌM, 126 ¦ÌM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
PRICE
29
DESCRIPTION
p-Coumaric acid is a hydroxy derivative of cinnamic acid that can be found in a variety of edible plants that is reported to have antioxidant, anti-inflammatory, and antimicrobial activity.
(Enamine Bioactive Compounds)
DESCRIPTION
p-Coumaric acid (para-Coumaric Acid) is the abundant isomer of cinnamic acid, with antitumor and anti-mutagenic activities.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
1
Compound Sets
11
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
67
Molecular Weight
164.05
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.49
TPSA
57.53
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Endogenous Metabolite
HCAR2, PTGR1
Apoptosis
Bacterial
Prostaglandin Receptor
MOA
Thrombin inhibitor
Prostaglandin Receptor inhibitor
Antibiotic
Pathway
Metabolism
Microbiology/virology
Anti-infection
Metabolic Enzyme/Protease
GPCR/G protein
Source data
