General
Preferred name
GLYCERIN
Synonyms
glycerol ()
Tixylix Baby ()
Glycerin,anhydrous ()
Glycogelatin ()
Senokot Direct Relief ()
Osmoglyn ()
Nirolex ()
INS-422 ()
INS NO.422 ()
Ophthalgan ()
Glycerol 85% ()
FEMA NO. 2525 ()
E422 ()
Keybells ()
Monoctanoin Component D ()
Glycerol ()
NSC-9230 ()
PZN 7474853 ()
Tixylix Toddler ()
Tryhydroxypropane ()
M 314429 ()
Optim ()
Glycerolum ()
Glycerinum ()
E-422 ()
Waterhouse ()
P&D ID
PD006499
CAS
56-81-5
29796-42-7
8043-29-6
175385-78-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1982
Drug Status
investigational
approved
Max Phase
Phase 4
Drug indication
Pharmaceutic Aid (humectant)
Pharmaceutic Aid (solvent)
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY Glycerol has very low toxicity when ingested ;; Rat LD50 (oral)-12600mg/kg; Mice LD50 (oral )-4090mg/kg; Human TDLo (oral) - 1428mg/kg ;
MOA When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. ; Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.
METABOLISM Glycerin is a substrate for synthesis of triacylglycerols and of phospholipids in the liver and adipose tissue. When fat metabolized as a source of energy, glycerol and fatty acids are released into the bloodstream. Circulating glycerin does not glycate proteins and does not lead to the formation of advanced glycation endproducts (AGEs). In some organisms, the glycerin component can enter the glycolysis pathway directly to provide a substrate for energy or glucose production. Glycerol must be converted to their intermediate glyceraldehyde 3-phosphate before being used in glycolysis or gluconeogenesis. Glycerol metabolism is regulated by the enzymes glycerol kinase, (cytosolic) NAD+-dependent G3P dehydrogenase and (mitochondrial) FAD-linked G3P dehydrogenase.
Cell lines
1
Organisms
0
Compound Sets
14
ChEMBL Approved Drugs
CHEMBL692
ChEMBL Drugs
CHEMBL692
DrugBank
DB09462
DrugBank Approved Drugs
DB09462
DrugCentral
1316
DrugCentral Approved Drugs
1316
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
5195
NCATS Inxight Approved Drugs
PDC6A3C0OX
ReFrame library
Selleckchem Bioactive Compound Library
glycerol
TargetMol Bioactive Compound Library
T4776
The Spectrum Collection
External IDs
52
Properties
(calculated by RDKit )
Molecular Weight
92.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.67
TPSA
60.69
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.38
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
Endogenous Metabolite
Source data