General
Preferred name
Quinolones
Synonyms
2-Hydroxyquinoline ()
2-Quinolone ()
P&D ID
PD006430
CAS
104534-80-7
1321-40-0
493-62-9
70254-42-1
59-31-4
Tags
available
drug
Drug indication
Tuberculosis
Bacterial infection
Drug Status
approved
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 2-Hydroxyquinoline is a potent ¦Á-glucosidase inhibitor with IC50 values of 64.4, 130.5 ¦Ìg/mL for ¦Á-glucosidase and ¦Á-amylase, respectively. 2-Hydroxyquinoline has the potential for the research of diabetes[1].
DESCRIPTION 2-quinolone is a selective carbonic anhydrase IX and XII inhibitor. (Enamine Bioactive Compounds)
Compound Sets
6
DrugBank
DB04745
DrugMAP
DM5GVHU
DrugMAP Approved Drugs
DM5GVHU
Enamine Bioactive Compounds
EBC-03213
EU-OPENSCREEN Bioactive Compound Library
EOS102257
MedChem Express Bioactive Compound Library
HY-W005598
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
145.05
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
1.53
TPSA
32.86
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Amylases
Glycosidase
Pathway
Metabolic Enzyme/Protease
Source data