General
Preferred name
AS-605240
Synonyms
AS605240 ()
KIN001-173 ()
AS 605240 ()
5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE ()
AS-605240 potassium salt ()
AS-605240 (potassium salt) ()
PI 3-Kg inhibitor ()
P&D ID
PD006408
CAS
648450-29-7
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
AS-605240 is a specific and orally active inhibitor of the PI3K¦Ã, with an IC50 of 8 nM, and a Ki of 7.8 nM.
DESCRIPTION
Dual irreversible inhibitor of ErbB2 and EGFR
(Tocris Bioactive Compound Library)
DESCRIPTION
Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
10
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
257.03
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
1.95
TPSA
71.95
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
PI3K signaling
Autophagy
PI3K/Akt/mTOR
Target
PI3K gamma
PI3K¦Â
PI3K¦Ã
PI3K¦Á
PI3K¦Ä
PI3K
Primary Target
PI 3-kinase
MOA
PI3K inhibitor
Inhibitor
Solubility
Soluble in water.
Source data
