General
Preferred name
Aftin-4
Synonyms
Aftin 4 ()
Aftin4 ()
(2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol ()
P&D ID
PD006401
CAS
866893-90-5
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Aftin-4 is an Amyloid-¦Â42 (A¦Â42) inducer.
PRICE 94
DESCRIPTION Aftin-4, an amyloid forty-two inducer, activates ??-secretase, promoting the generation of amyloid-??-1-42 (A??1-42) from amyloid-?? protein precursor. Aftin-4(Aftin4) increased A??-1-42, but not A??-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
DESCRIPTION Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain. (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
27341
DrugBank
DB04776
MedChem Express Bioactive Compound Library
HY-111267
TargetMol Bioactive Compound Library
T4364
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
368.23
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
3
cLogP
3.23
TPSA
79.1
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Amyloid-¦Â
Amyloid-β
γ secretase(Aβ42)
Amyloid-??
Pathway
Neuronal Signaling
Neuroscience
Proteases/Proteasome
Stem Cells
Source data