General
Preferred name
BETA-NAPHTHOFLAVONE
Synonyms
β-Naphthoflavone ()
beta-NF ()
5,6-Benzoflavone ()
Dulcitol ()
Melampyrit ()
NSC 1944 ()
¦Â-Naphthoflavone ()
?-Naphthoflavone ()
P&D ID
PD006366
CAS
6051-87-2
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ¦Â-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. ¦Â-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. ¦Â-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. ¦Â-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to treat aristolochic acid (AAI) induced renal injury[1][2][3].
PRICE 29
DESCRIPTION 5,6-Benzoflavone (??-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (??-Naphthoflavone) possesses anti-inflammatory and antioxidant activities, inhibits LPS-induced inflammation through the AKT/Nrf-2/HO-1-NF-kappaB signaling axis, inhibits TNF-??-induced ICAM-1 and VCAM-1 expression, which can be used to study neurodegenerative diseases.
DESCRIPTION 5,6-Benzoflavone is a polyaromatic hydrocarbon receptor agonist that induces detoxification enzymes such as P450. (BOC Sciences Bioactive Compounds)
DESCRIPTION 5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses anti-inflammatory and antioxidant activities, inhibits LPS-induced inflammation through the AKT/Nrf-2/HO-1-NF-kappaB signaling axis, inhibits TNF-α-induced ICAM-1 and VCAM-1 expression, which can be used to study neurodegenerative diseases. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
7
BOC Sciences Bioactive Compounds
5-6-benzoflavone-cas-6051-87-2-item-129132
Cayman Chemical Bioactives
34040
DrugBank
DB06732
EU-OPENSCREEN Bioactive Compound Library
EOS102349
MedChem Express Bioactive Compound Library
HY-114740
Selleckchem Bioactive Compound Library
dulcite
TargetMol Bioactive Compound Library
TN6694
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
272.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
4
cLogP
4.61
TPSA
30.21
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Apoptosis
Aryl hydrocarbon receptor
antioxidant
Sirtuin
Pathway
Immunology/Inflammation
oxidation-reduction
Source data