General
Preferred name
SB220025
Synonyms
SB-220025-R ()
SB-220025-A ()
SB 220025 ()
SB-220025 ()
P&D ID
PD006294
CAS
165806-53-1
Tags
available
drug candidate
Drug indication
Arthritis
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SB220025 cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP kinases .
(GtoPdb)
DESCRIPTION
SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC50 = 60 nM). SB 220025 also inhibits p56Lck and PKC with IC50 values of 3.5 and 2.89 ¦ÌM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation[1][2].
PRICE
815
DESCRIPTION
SB220025 is a specific and potent inhibitor of human p38 mitogen-activated protein kinase (IC50 = 19nM).
(Enamine Bioactive Compounds)
DESCRIPTION
SB220025 is an orally available, selective and potent inhibitor of P38 mitogen-activated protein kinase that inhibits p56Lck and PKC, inhibits endothelial growth hormone-induced Ca(2+) signaling, and inhibits angiogenesis, and can be used in the study of arthritis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
DrugBank
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
GSK Published Kinase Inhibitor Set
Guide to Pharmacology
Kinase Chemogenomic Set (KCGS 08/2017, in progress)
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
338.17
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
2.65
TPSA
81.65
Fraction CSP3
0.28
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
p38a
p38
PKC
p38 MAPK
SRC
MAPK14
Pathway
Chromatin/Epigenetic
Cytoskeletal Signaling
MAPK
Epigenetics
MAPK/ERK Pathway
Protein Tyrosine Kinase/RTK
TGF-beta/Smad
Source data
