General
Preferred name
ARECOLINE
Synonyms
ARECOLINE HYDROBROMIDE ()
Arecoline HBr ()
Arecoline bromide ()
NSC-31750 ()
Arecoline (hydrobromide) ()
NSC-56321 ()
P&D ID
PD006273
CAS
300-08-3
63-75-2
131448-18-5
Tags
available
drug candidate
natural product
biased GPCR ligand
Drug indication
Parkinson disease
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Arecoline is an alkaloid derived from the betel nut. It acts as a cholinomimetic.
(GtoPdb)
PRICE
29
DESCRIPTION
Acetylcholine receptor agonist
(LOPAC library)
DESCRIPTION
Arecoline hydrobromide is a natural alkaloid that is found in the betel nut of the Areca palm. It is a muscarinic acetylcholine receptor agonist.
(Enamine Bioactive Compounds)
DESCRIPTION
Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Arecoline is a natural alkaloid derived from areca nut in the palm family and is a potent nicotine and partial agonist of muscarinic acetylcholine receptors. Arecoline has anti-anxiety and anti-parasitic activity, can induce oxidative stress and can be used to study Alzheimer's disease and Alzheimer's disease.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
23
AdooQ Bioactive Compound Library
BiasDB
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
155.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
0.42
TPSA
29.54
Fraction CSP3
0.62
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Nicotinic Receptor
AChR
Reactive Oxygen Species
mAChR
CHRM1, CHRM2, CHRM3, CHRM4
Member status
virtual
MOA
Muscarinic Receptor Agonists
Potassium Channel Subfamily K Member 18 (TRESK KCNK18) Blockers
acetylcholine receptor agonist
Pathway
Immunology/Inflammation
Metabolism
Neuroscience
NF-κB
Source data
