General
Preferred name
ALDOSTERONE
Synonyms
CHEMBL273453 ()
[3H]aldosterone ()
Aldosterona ()
NSC-73856 ()
P&D ID
PD005950
CAS
52-39-1
10328-70-8
Tags
probe
drug
available
Drug indication
Hypertension
Drug Status
approved
experimental
investigational
Max Phase
2.0
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
High-quality chemical probes
Tool Compound Set
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].
PRICE 430
DESCRIPTION Aldosterone, the primary mineralocorticoid, is synthesized and secreted by the zona glomerulosa of the adrenal cortex in response to activation of the renin-angiotensin system or high dietary potassium.
Compound Sets
18
Cayman Chemical Bioactives
15273
ChEMBL Drugs
CHEMBL273453
Concise Guide to Pharmacology 2017/18
3452
2872
Concise Guide to Pharmacology 2019/20
3452
2872
Concise Guide to Pharmacology 2021/22
3452
2872
Concise Guide to Pharmacology 2023/24
3452
2872
DrugBank
DB04630
DrugCentral
111
DrugCentral Approved Drugs
111
DrugMAP
DM9S2JW
DrugMAP Approved Drugs
DM9S2JW
Guide to Pharmacology
3452
2872
High-quality chemical probes
PD005950
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL273453
MedChem Express Bioactive Compound Library
HY-113313
NURSA ligand set
nursa/index.jsf?doi=10.1621%2F2ZTYUZWU7P
Tool Compound Set
ZINC Tool Compounds
ZINC000003833824
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
360.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
0
cLogP
1.85
TPSA
91.67
Fraction CSP3
0.76
Chiral centers
7.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Mineralocorticoid Receptor
Endogenous Metabolite
Therapeutic Class
Antihypertensive Agents
Pathway
Metabolic Enzyme/Protease
Source data