General
Preferred name
PD005887
Synonyms
25-hydroxycholesterol ()
25-OHC ()
25-hydroxy Cholesterol ()
25-hydroxy Cholesterol-d6 ()
P&D ID
PD005887
CAS
2140-46-7
88247-69-2
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent P-glycoprotein (P-gp) inhibitor (Tocris Bioactive Compound Library)
Compound Sets
14
Cayman Chemical Bioactives
11097
11099
Concise Guide to Pharmacology 2017/18
2885
Concise Guide to Pharmacology 2019/20
2885
Concise Guide to Pharmacology 2021/22
2885
Concise Guide to Pharmacology 2023/24
2885
DrugBank
DB04705
DrugMAP
DMCHAQ7
EU-OPENSCREEN Bioactive Compound Library
EOS101659
Guide to Pharmacology
2885
MedChem Express Bioactive Compound Library
HY-113134
Novartis Chemogenetic Library (NIBR MoA Box)
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FKKEHSMRCA5
TargetMol Bioactive Compound Library
T4717
Tocris Bioactive Compound Library
5741
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
402.35
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
0
cLogP
6.5
TPSA
40.46
Fraction CSP3
0.93
Chiral centers
8.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Metabolism
Metabolic Enzyme/Protease
Target
HMG-CoA Reductase
Endogenous Metabolite
Primary Target
Antivirals
Member status
member
MOA
Apoptosis Inducers
IL-8 Modulators
TNF-alpha Release Inhibitors
Cholesterol Biosynthesis Inhibitors
3-hydroxy-3-methylglutaryl-CoA reductase Inhibitors
Source data