General
Preferred name
A 1120
Synonyms
2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid ()
A1120 ()
A-1120 ()
P&D ID
PD005718
CAS
1152782-19-8
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION A1120 is reported as a potent non-retinoid inhibitor of plasma retinol-binding protein RBP4 . (GtoPdb)
DESCRIPTION High affinity retinol-binding protein 4 (RBP4) ligand (Tocriscreen Plus)
DESCRIPTION Selective sigma (sigma) agonist (sigma1> sigma2) (Tocris Bioactive Compound Library)
DESCRIPTION A 1120 is a retinol-binding protein 4 (RBP4) antagonist (Ki = 8.3 nM) that can reduce serum RBP4 and retinol, and displaces transthyretin (TTR) from RBP4-TTR complexes. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
14
BOC Sciences Bioactive Compounds
a-1120-cas-1152782-19-8-item-271974
Cayman Chemical Bioactives
30921
Concise Guide to Pharmacology 2017/18
8792
Concise Guide to Pharmacology 2019/20
8792
Concise Guide to Pharmacology 2021/22
8792
Concise Guide to Pharmacology 2023/24
8792
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB06985
Guide to Pharmacology
8792
MedChem Express Bioactive Compound Library
HY-107633
ReFrame library
Tocris Bioactive Compound Library
3793
Tocriscreen Plus
3793
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
392.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.82
TPSA
69.64
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Other Pharmacology
Primary Target
Miscellaneous Compounds
Target
RBP4
Transthyretin (TTR)
MOA
retinoid receptor ligand
Pathway
Neuronal Signaling
Source data