General
Preferred name
DR 2313
Synonyms
DR2313 ()
DR-2313 ()
2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one ()
CHEMBL483348 ()
P&D ID
PD005561
CAS
284028-90-6
Tags
available
drug candidate
obsolete probe
Drug indication
Stroke
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
DR2313 is a potent, selective, competitive and brain-penetrant inhibitor of poly(ADP-ribose) polymerase (PARP), with IC50s of 0.20 ¦ÌM and 0.24 ¦ÌM for PARP-1 and PARP-2, respectively. DR2313 exhibits neuroprotective effects on ischemic injuries in vitro and in vivo[1][2].
PRICE
29
DESCRIPTION
DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 ??M for PARP-1 and PARP-2 respectively). It also has neuroprotective.
DESCRIPTION
Potent, orally active human leukocyte elastase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent PARP inhibitor
(Tocriscreen Total)
DESCRIPTION
DR 2313 has been found to be a PARP-1/PARP-2 inhibitor and could exhibit neuroprotective avtivities as well as reduce cortical infarct volume in focal ischemia.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
Obsolete Compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
182.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
0.87
TPSA
45.75
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
PARP
PARP1
PARP2
PARP1, PARP3
Primary Target
Poly(ADP-ribose) Polymerase
MOA
Inhibitor
PARP inhibitor
Pathway
Cell Cycle/DNA Damage
Epigenetics
Chromatin/Epigenetic
DNA Damage/DNA Repair
Source data
