General
Preferred name
DEOXYCHOLIC ACID
Synonyms
Sodium Desoxycholate ()
Atx-101 ()
deoxycholic acid, Kythera ()
Deoxycholic acid sodium salt ()
Cholanoic Acid ()
Desoxycholic acid ()
Sodium deoxycholate ()
Deoxycholate, Desoxycholic acid, Cholerebic, Cholorebic ()
Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA ()
Deoxycholic Acid-d4 ()
Deoxycholic Acid (sodium salt hydrate) ()
DWJ-211 ()
ACIDE DESOXYCHOLIQUE ()
Kybella ()
ACIDO DESOXICOLICO ()
ATX-101 (DEOXYCHOLIC ACID) ()
DWJ211 ()
NSC-8797 ()
Deoxycholic Acid MaxSpec® Standard ()
Deoxycholic Acid-d4 MaxSpec® Standard ()
P&D ID
PD005549
CAS
115349-14-9
83-44-3
302-95-4
112076-61-6
145224-92-6
Tags
available
drug
Approved by
FDA
First approval
2015
Drug indication
Obesity
Fat below the chin
lipoma
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Endogenous deoxycholic acid is a secondary bile acid produced by intestinal bacteria. Bile acids help the body absorb dietary fats from the gut.
(GtoPdb)
DESCRIPTION
Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2].
DESCRIPTION
Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Deoxycholic acid is specifically responsible for activating the G-protein-coupled bile acid receptor TGR5, stimulating the thermogenic activity of brown adipose tissue (BAT).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. Deoxycholic acid is a cytolytic agent used for improvement in appearance of moderate to severe fullness associated with submental fat in adults.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
1
Compound Sets
25
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
93
Molecular Weight
392.29
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
0
cLogP
4.48
TPSA
77.76
Fraction CSP3
0.96
Chiral centers
10.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
GPCR19
biliverdin reductase A activator, G protein-coupled receptor agonist
Target
TGR5
FPR1, GPBAR1
Endogenous Metabolite
G protein-coupled Bile Acid Receptor 1
Indication
submental fat
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Solubility
Soluble in DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
Recommended Cell Concentration
None
Source data
