General
Preferred name
L-778123
Synonyms
L 778123 ()
L-778123 hydrochloride ()
L-778123 (hydrochloride) ()
L-778,123 ()
L-778,123 (hydrochloride) ()
P&D ID
PD005440
CAS
253863-00-2
183499-57-2
Tags
available
drug candidate
probe
Drug indication
Lymphoma
Drug Status
experimental
investigational
Max Phase
Phase 1
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
29
No orthogonal probes found
Similar probes
2
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination ofL-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
1
Compound Sets
11
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
Probe Miner (suitable probes)
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
405.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
3.31
TPSA
65.16
Fraction CSP3
0.23
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
DNA Damage/DNA Repair
Metabolic Enzyme/Protease
Target
Farnesyl transferase (FTase)
FPTase
FNTA, FNTB, PGGT1B
Farnesyl Transferase
MOA
farnesyltransferase inhibitor
Source data
