General
Preferred name
FBPase-1 inhibitor-1
Synonyms
Fructose 1,6-bisphosphatase-1 Inhibitor ()
FBPase-1 inhibitor ()
Fructose-1,6-bisphosphatase-1 Inhibitor ()
2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE ()
P&D ID
PD005357
CAS
883973-99-7
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fructose-1,6-bisphosphatase-1 (FBPase-1) inhibitor is a cell-permeable benzoxazolo-sulfonamide compound functioning by blocking human FBPase-1 enzymatic activity with an IC50 value of 3.4 µM (Ki = 1.1 µM).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugBank
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
375.92
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
4.59
TPSA
72.2
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
FBPase-1
FBPase-1 inhibitor
FBPase
Carbohydrate Metabolism
Pathway
Metabolic Enzyme/Protease
Source data
