General
Preferred name
H-8
Synonyms
H-8 dihydrochloride ()
H-8 (dihydrochloride) ()
N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide ()
dihydrochloride ()
H-8 hydrochloride ()
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE ()
H-8 (hydrochloride) ()
P&D ID
PD005267
CAS
90327-91-6
84478-11-5
113276-94-1
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor[1].
PRICE
136
DESCRIPTION
Potent inhibitor of cAMP- and cGMP-dependent protein kinase
(LOPAC library)
DESCRIPTION
H-8 is a cell-permeable and potent inhibitor of PKA and PKG with Ki values of 1.2 and 0.48 µM, respectively. It also slightly inhibits PKC and MLCK with Ki values of 15 and 68 µM.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugMAP
DrugMatrix
Guide to Pharmacology
LINCS compound set
LOPAC library
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
265.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
0.73
TPSA
71.09
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PKA, PKG
Target
PKA
Pathway
Stem Cell/Wnt
TGF-beta/Smad
Tyrosine Kinase/Adaptors
Source data
