General
Preferred name
S-23
Synonyms
(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide ()
S23 ()
P&D ID
PD005202
CAS
1010396-29-8
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats[1][2].
PRICE 55
DESCRIPTION S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats. (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
27304
DrugBank
DB07419
MedChem Express Bioactive Compound Library
HY-112257
TargetMol Bioactive Compound Library
T20789
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
416.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
4.14
TPSA
82.35
Fraction CSP3
0.22
Chiral centers
1.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Androgen Receptor
Pathway
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Source data