General
Preferred name
CGS-27023
Synonyms
MMI270 ()
CGS-27023A ()
CGS 27023A ()
P&D ID
PD005077
CAS
161314-70-1
161314-82-5
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION CGS-27023A is reported as a potent pan-inhibitor of matrix metalloproteinases .
Note that CGS-27023A imay be used experimentally as the hydrochloride salt (PubChem CID 9888897). (GtoPdb)
PRICE 109
DESCRIPTION CGS 27023A is a non-peptidic, potent, and orally active stromelysin inhibitor. (TargetMol Bioactive Compound Library)
Compound Sets
7
CZ-OPENSCREEN Bioactive Library
DrugBank
DB07556
DrugMAP
DM38N2K
Guide to Pharmacology
8846
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T3472
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
393.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
1.81
TPSA
108.83
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
MMP
Member status
member
MOA
MMP-2 (Gelatinase A) Inhibitors
MMP-9 (Gelatinase B) Inhibitors
MMP-8 (Neutrophil Collagenase) Inhibitors
Angiogenesis Inhibitors
Matrix metalloproteinase inhibitor
"MMP-2 (Gelatinase A) Inhibitors
Matrix metalloproteinase inhibitor"
Pathway
Proteases/Proteasome
Source data