General
Preferred name
(5BETA)-PREGNANE-3,20-DIONE
Synonyms
5β-pregnane-3,20-dione ()
5β-Dihydroprogesterone ()
5βDHP ()
5¦Â-Dihydroprogesterone ()
3,20-Pregnanedione ()
5β-pregnane-3,20-dione ()
5¦ÂDHP ()
5?-Dihydroprogesterone ()
P&D ID
PD005076
CAS
128-23-4
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
5¦Â-Dihydroprogesterone (5¦ÂDHP) is the metabolite of Progesterone (HY-N0437). 5¦Â-Dihydroprogesterone binds to oxytocin receptor, reduces the Oxytocin (HY-17571)-induced calcium signal transduction, thereby exhibiting the tocolytic activity[1].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NURSA ligand set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
316.24
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
0
cLogP
4.8
TPSA
34.14
Fraction CSP3
0.9
Chiral centers
7.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Oxytocin Receptor
Pathway
GPCR/G protein
Source data
