General
Preferred name
SD-0006
Synonyms
SD-06 ()
SD 0006 ()
SD0006 ()
P&D ID
PD004867
CAS
271576-80-8
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38¦Á MAP kinase, with an IC50 of 110 nM for p38¦Á[1][2].
PRICE 70
DESCRIPTION SD 0006 (SD-06) is a MAPK p38 alpha inhibitor with an IC50 of 110 nM, indicated for the treatment of arthritis. (TargetMol Bioactive Compound Library)
Compound Sets
9
Cayman Chemical Bioactives
30686
ChEMBL Drugs
CHEMBL1090173
Drug Repurposing Hub
DrugBank
DB07943
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1090173
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL1090173
MedChem Express Bioactive Compound Library
HY-11087
ReFrame library
TargetMol Bioactive Compound Library
T7276
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
397.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
2.89
TPSA
95.0
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Autophagy
MAPK
MAPK/ERK Pathway
MOA
p38 MAPK inhibitor
Target
p38 MAPK
Source data