General
Preferred name
AMG-208
Synonyms
AMG 208 ()
AMG208 ()
Amg 208 ()
P&D ID
PD004808
CAS
1002304-34-8
Tags
available
drug candidate
Drug indication
Prostate cancer
Solid tumour/cancer
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 74
DESCRIPTION AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers. (BOC Sciences Bioactive Compounds)
DESCRIPTION AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1. (TargetMol Bioactive Compound Library)
Compound Sets
13
AdooQ Bioactive Compound Library
A10063
Axon Medchem Screening Library
1916
BOC Sciences Bioactive Compounds
amg208-cas-1002304-34-8-item-84-286328
Cayman Chemical Bioactives
24197
ChEMBL Drugs
CHEMBL496102
Clinical kinase drugs
Drug Repurposing Hub
DrugBank
DB08079
DrugMAP
DMPQHOR
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL496102
MedChem Express Bioactive Compound Library
HY-12035
ReFrame library
TargetMol Bioactive Compound Library
T6260
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
383.14
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
5
cLogP
3.93
TPSA
74.43
Fraction CSP3
0.09
Chiral centers
0.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
c-Met/HGFR
Cytochrome P450
c-Met
MET inhibitor
Targets
MET
MOA
c-Met/HGFR inhibitor
tyrosine kinase inhibitor
Pathway
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
Metabolism
Tyrosine Kinase/Adaptors
Source data