General
Preferred name
LT175
Synonyms
(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid ()
P&D ID
PD004727
CAS
862901-87-9
Tags
drug candidate
available
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
LT175, a dual PPAR¦Á/¦Ã ligand, is an orally active partial agonist against PPAR¦Ã(hPPAR¦Á:EC50=0.22 ¦Ìm; mPPAR¦Á:EC50=0.26 ¦Ìm; hPPAR¦Ã:EC50=0.48 ¦Ìm). LT175 interacts with PPAR¦Ã and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPAR¦Ã in a hydrophobic region called "diphenyl pocket" . LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].
DESCRIPTION
LT175 is a dual PPARα/γ ligand with partial agonist activity against PPARγ. LT175 exhibits low adipogenic activity, and decreased body weight, adipocyte size, and white adipose tissue mass in mice fed a high-fat diet. It improves glucose homeostasis and insulin sensitivity.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
318.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
4.43
TPSA
46.53
Fraction CSP3
0.1
Chiral centers
1.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PPAR
Pathway
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data
