General
Preferred name
MYRISTIC ACID
Synonyms
n-Tetradecanoic acid ()
Tetradecanoic acid ()
Crodacid ()
PHILACID-1400 ()
N-tetradecan-1-oic acid ()
Myristate ()
FEMA NO. 2764 ()
PRIFRAC-2942 ()
NSC-5028 ()
Myristic Acid-d27 ()
Myristic Acid-13C ()
Myristic Acid-d2 ()
Myristic Acid-d7 ()
P&D ID
PD004622
CAS
67701-02-4
45184-05-2
544-63-8
60658-41-5
57677-52-8
30719-21-2
Tags
available
covalent binder
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Myristic acid is an orally active saturated 14-carbon fatty acid found in most animal and plant fats, especially milk fat coconut oil, palm oil and nutmeg oil. Myristic acid exerts anti-inflammatory activity through the NF-¦ÊB pathway. Myristic acid has antibacterial, anti-inflammatory and analgesic properties[1][2][3][4].
PRICE
29
DESCRIPTION
Myristic acid (Crodacid) , a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N-terminal glycine residues, in a process called N-terminal myristoylation. Myristoylation of substrate proteins by this fatty acid has the potential to activate and mediate many physiological pathways. Furthermore, saturated fatty acids have been reported to be essential for biological activities of lipopolysaccharides and have demonstrated the ability to induce expression of COX-2 and NF??B (nuclear factor ??B) activation.
DESCRIPTION
Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats. It has antibiotic activity.
(Enamine Bioactive Compounds)
DESCRIPTION
Myristic acid (Crodacid) , a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N-terminal glycine residues, in a process called N-terminal myristoylation. Myristoylation of substrate proteins by this fatty acid has the potential to activate and mediate many physiological pathways. Furthermore, saturated fatty acids have been reported to be essential for biological activities of lipopolysaccharides and have demonstrated the ability to induce expression of COX-2 and NFκB (nuclear factor κB) activation.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
14
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
64
Molecular Weight
228.21
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
12
Ring Count
0
Aromatic Ring Count
0
cLogP
4.77
TPSA
37.3
Fraction CSP3
0.93
Chiral centers
0.0
Largest ring
0.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Bacterial
NF-κB
SRC
Pathway
Metabolism
Anti-infection
Metabolic Enzyme/Protease
NF-¦ÊB
Source data
