General
Preferred name
ZM 241385
Synonyms
ZM-241385 ()
[3H]ZM 241385 ()
ZM241385 ()
4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol ()
[3H]ZM 241385 ()
[3H]-ZM-241385 ()
P&D ID
PD004548
CAS
139180-30-6
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3].
PRICE 60
DESCRIPTION mGlu5 selective agonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent, highly selective A2A antagonist (Tocriscreen Plus)
DESCRIPTION Potent, highly selective A2A antagonist (Tocriscreen Total)
DESCRIPTION ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
19
AdooQ Bioactive Compound Library
A13517
Cayman Chemical Bioactives
20447
Concise Guide to Pharmacology 2017/18
405
455
Concise Guide to Pharmacology 2019/20
405
455
Concise Guide to Pharmacology 2021/22
405
455
Concise Guide to Pharmacology 2023/24
405
455
Drug Repurposing Hub
DrugBank
DB08770
DrugMAP
DMWQ38G
DMKU4YQ
EUbOPEN Chemogenomics Library
EUB0000417
Guide to Pharmacology
405
455
Ki Database
ZM 241385
MedChem Express Bioactive Compound Library
HY-19532
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
zm241385
TargetMol Bioactive Compound Library
T7021
Tocris Bioactive Compound Library
1036
Tocriscreen Plus
1036
Tocriscreen Total
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
337.13
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
4
cLogP
1.72
TPSA
127.39
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
Adenosine A2A Receptors
MOA
Antagonist
Adenosine A2A Antagonists
Adenosine A2B Antagonists
Adenosine Receptor antagonist
Member status
member
Target
ADORA1, ADORA2A, ADORA2B, ADORA3
Adenosine Receptor
A2A
Pathway
GPCR/G protein
Neuroscience
Recommended Cell Concentration
100 nM
Source data