General
Preferred name
ZOPOLRESTAT
Synonyms
CP 73850 ()
CP73850 ()
CP-73850 ()
Zopolrestatum ()
Alond ()
CP-73,850 ()
P&D ID
PD004546
CAS
110703-94-1
Tags
available
drug candidate
Drug indication
Diabetic complication
Drug Status
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications[1].
PRICE 83
DESCRIPTION Zopolrestat is an experimental aldose reductase inhibitor. (GtoPdb)
DESCRIPTION Zopolrestat is a potent, orally active aldose reductase (AR) inhibitor. Zopolrestat is used for the research of diabetic complications. (Enamine Bioactive Compounds)
DESCRIPTION Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM). (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
11
Cayman Chemical Bioactives
29185
ChEMBL Drugs
CHEMBL10372
Drug Repurposing Hub
DrugBank
DB08772
DrugMAP
DMWOT92
DrugMatrix
Enamine Bioactive Compounds
EBC-499076
Guide to Pharmacology
7419
Ki Database
zopolrestat
MedChem Express Bioactive Compound Library
HY-19687
TargetMol Bioactive Compound Library
T35317
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
419.06
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
3.7
TPSA
85.08
Fraction CSP3
0.16
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Aldose Reductase
AKR1B1, AKR1B10
Pathway
Endocrinology/Hormones
Metabolism
Metabolic Enzyme/Protease
Source data