General
Preferred name
AMPEROZIDE
Synonyms
AMPEROZIDE HYDROCHLORIDE ()
Amperozida ()
FG 5606 ()
Amperozidum ()
P&D ID
PD004521
CAS
75558-90-6
75529-73-6
Tags
drug
available
Drug indication
Alcohol dependence
Drug Status
approved
investigational
experimental
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amperozide is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a Ki value of 26 nM. Amperozide has a low affinity for D2 receptors[1].
PRICE 276
DESCRIPTION Amperozide (FG 5606) is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily around its capability for treating schizophrenia in humans. (TargetMol Bioactive Compound Library)
DESCRIPTION Atypical antipsychotic drug with high affinity for serotonin receptors and low affinity for D2 dopamine receptors (LOPAC library)
Cell lines
1
Organisms
2
Compound Sets
14
ChEMBL Drugs
CHEMBL1079935
Drug Repurposing Hub
DrugBank
DB08927
DrugCentral
193
DrugCentral Approved Drugs
193
DrugMAP
DMDAMBW
DrugMatrix
Ki Database
AMPEROZIDE
LOPAC library
MedChem Express Bioactive Compound Library
HY-121301
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T23733
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
401.23
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
4.22
TPSA
35.58
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
5-HT2
FAAH, HTR2A
Member status
member
MOA
"5-HT2A Antagonists
Dopamine D2 Antagonists"
5-HT2A Antagonists
Dopamine D2 Antagonists
Dopamine Receptor antagonist
Indication
psychosis
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data