General
Preferred name
PJ34
Synonyms
PJ 34 hydrochloride ()
PJ34 hcl ()
PJ34 hydrochloride ()
PJ 34 ()
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE ()
PJ34 (hydrochloride) ()
PARP Inhibitor VIII, PJ34 ()
PJ-34 HCL ()
PJ-34 (hydrochloride) ()
P&D ID
PD004483
CAS
344458-19-1
344458-15-7
Tags
available
obsolete probe
drug candidate
Drug indication
Coronavirus infection
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PJ34 is a poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor . It is a tool compound that is active in vitro and in vivo. PARP-1 inhibitors downregulate multiple pathways of inflammation and tissue injury, and a number of potent inhibitors have been developed for anti-cancer potential..
(GtoPdb)
DESCRIPTION
Thymidylate synthetase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent PARP inhibitor
(Tocriscreen Plus)
DESCRIPTION
PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
17
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
Novartis Chemogenetic Library (NIBR MoA Box)
Obsolete Compounds
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
295.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
2.18
TPSA
65.2
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Chromatin/Epigenetic
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Epigenetics
Target
PARP1
PARP2
PARP
EEF2, PARP1, PARP15, PARP3
Primary Target
Poly(ADP-ribose) Polymerase
MOA
Inhibitor
NAD+ ADP-Ribosyltransferase (poly(ADP-ribose)polymerase PARP) Inhibitors
poly(ADP-ribose) Glycohydrolase (PARG) Inhibitors
PARP inhibitor
Member status
member
Source data
