General
Preferred name
PJ34
Synonyms
PJ 34 hydrochloride ()
PJ34 hcl ()
PJ 34 ()
PARP Inhibitor VIII, PJ34 ()
PJ34 (hydrochloride) ()
PJ-34 HCL ()
PJ34 hydrochloride ()
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE ()
PJ-34 ()
P&D ID
PD004483
CAS
344458-15-7
344458-19-1
Tags
available
drug candidate
obsolete probe
Drug indication
Coronavirus infection
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.
PRICE 35
DESCRIPTION PJ34 is a poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor . It is a tool compound that is active in vitro and in vivo. PARP-1 inhibitors downregulate multiple pathways of inflammation and tissue injury, and a number of potent inhibitors have been developed for anti-cancer potential.. (GtoPdb)
PRICE 40
DESCRIPTION Thymidylate synthetase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Potent PARP inhibitor (Tocriscreen Plus)
DESCRIPTION PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2. (TargetMol Bioactive Compound Library)
DESCRIPTION PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively. (BOC Sciences Bioactive Compounds)
DESCRIPTION PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
17
AdooQ Bioactive Compound Library
A12665
A15215
BOC Sciences Bioactive Compounds
pj-34-hcl-cas-344458-19-1-item-84-462712
Cayman Chemical Bioactives
14440
Drug Repurposing Hub
DrugBank
DB08348
DrugMAP
DMXO6YH
Guide to Pharmacology
11348
MedChem Express Bioactive Compound Library
HY-13688
HY-13688A
Novartis Chemogenetic Library (NIBR MoA Box)
Obsolete Compounds
pj34
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
pj34-hcl
TargetMol Bioactive Compound Library
T2124
T6197
Tocris Bioactive Compound Library
3255
Tocriscreen Plus
3255
ZINC Tool Compounds
ZINC000000008960
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
295.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
2.18
TPSA
65.2
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
PARP
PARP1
PARP2
EEF2, PARP1, PARP15, PARP3
Primary Target
Poly(ADP-ribose) Polymerase
MOA
Inhibitor
NAD+ ADP-Ribosyltransferase (poly(ADP-ribose)polymerase PARP) Inhibitors
poly(ADP-ribose) Glycohydrolase (PARG) Inhibitors
PARP inhibitor
Member status
member
Pathway
Cell Cycle/DNA Damage
Epigenetics
Chromatin/Epigenetic
DNA Damage/DNA Repair
Source data