General
Preferred name
PhiKan 083
Synonyms
1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine ()
PhiKan 083 hydrochloride ()
P&D ID
PD004468
CAS
1050480-30-2
880813-36-5
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 ¦ÌM[1], and a relative binding affinity (Kd) of 150 ¦ÌM in Ln229 cells[3].
DESCRIPTION PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 ¦ÌM. PhiKan 083 can be used for cancer research[1].
PRICE 62
DESCRIPTION Inhibitor of Wnt/beta-catenin signaling (Tocris Bioactive Compound Library)
DESCRIPTION p53 stabilizing agent (Tocriscreen Plus)
DESCRIPTION PhiKan 083, a carbazole derivative, exhibits potential as an eco-friendly dye with applications in the development of organic photovoltaic cells (OPVs). (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
0
Compound Sets
8
Drug Repurposing Hub
DrugBank
DB08363
DrugMAP
DMC3PYM
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-108637A
HY-108637
TargetMol Bioactive Compound Library
T16523L
Tocris Bioactive Compound Library
4326
Tocriscreen Plus
4326
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
238.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
3.53
TPSA
16.96
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Primary Target
p53
Target
TP53
MDM-2/p53
p53/MDM2
MOA
p53 stabilizing agent
Pathway
Apoptosis
Source data