General
Preferred name
mardepodect
Synonyms
PF-2545920 ()
PF-02545920 ()
Mardepodect (hydrochloride) ()
PF-2545920 (hydrochloride) ()
Mardepodect (PF-2545920) ()
MP-10 ()
PF-2545920 ()
P&D ID
PD004447
CAS
1292799-56-4
1037309-45-7
898562-94-2
2070014-78-5
Tags
available
drug candidate
Drug indication
Huntington disease
Schizophrenia
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Mardepodect (PF-2545920) is a selective, orally active inhibitor of phosphodiesterase (PDE) 10A . Identified using structure-based drug design, the compound is optimised for selectivity, brain penetration and drug-like properties. PF-2545920 is the first PDE10A inhibitor identified as a clinical lead utilizing this mechanism for the treatment of schizophrenia.
(GtoPdb)
DESCRIPTION
PF-2545920 is a selective, orally active inhibitor of phosphodiesterase (PDE) 10A . Identified using structure-based drug design, the compound is optimised for selectivity, brain penetration and drug-like properties. Proposed INN is mardepodect. PF-2545920 is the first PDE10A inhibitor identified as a clinical lead utilizing this mechanism for the treatment of schizophrenia.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
17
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
392.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
5
cLogP
5.28
TPSA
52.83
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
PDE10A
Phosphodiesterase (PDE)
PDE
Member status
member
MOA
Phosphodiesterase 10A Inhibitors
phosphodiesterase inhibitor
Source data
