General
Preferred name
Puromycin
Synonyms
CL13900 dihydrochloride ()
Puromycin 2HCl ()
Puromycin dihydrochloride ()
Puromycin dihydrochloride from Streptomyces alboniger ()
Puromycin (Dihydrochloride) ()
CL13900 ()
CL13900 (dihydrochloride) ()
PUROMYCIN HYDROCHLORIDE ()
Puromycin (hydrochloride) ()
CL 16,536 ()
P-638 DIHYDROCHLORIDE ()
CL-13900 DIHYDROCHLORIDE ()
NSC-3055 ()
CL-16536 ()
CL 13,900 ()
3123-L ()
CL-13900 ()
Puromicina ()
P-638 ()
TCMDC-123493 ()
GNF-Pf-2016 ()
Puromycine ()
3123L ()
P&D ID
PD004400
CAS
58-58-2
53-79-2
Tags
available
drug candidate
natural product
Drug indication
Bacterial infections
Drug Status
experimental
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis[1].
PRICE
40
DESCRIPTION
Puromycin is an aminoacyl nucleoside antimicrobial compound, originally isolated from Streptomyces alboniger . It is a potent inhibitor of protein translation in both eukaryotic and prokaryotic organisms and has not been of clinical utility due to its non-selective systemic toxicity. Instead it is used extensively in the laboratory to study mechanisms of protein synthesis and also as a selective agent in mammalian cell culture systems (reviewed in ).
Please note that puromycin was formerly known as achromycin, which was also a trade name used for . (GtoPdb)
Please note that puromycin was formerly known as achromycin, which was also a trade name used for . (GtoPdb)
DESCRIPTION
Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.
DESCRIPTION
Alkylating agent; chemotherapeutic
(Tocris Bioactive Compound Library)
DESCRIPTION
Puromycin dihydrochloride (CL13900 dihydrochloride) is a cinnamamide adenosine antibiotic and an inhibitor of protein synthesis. Puromycin dihydrochloride inhibits protein synthesis by binding to RNA and has antitumor and antitrypanosomal activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
13
Organisms
5
Compound Sets
12
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
471.22
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
4
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
-0.79
TPSA
160.88
Fraction CSP3
0.45
Chiral centers
5.0
Largest ring
6.0
QED
0.33
Structural alerts
1
Protein disruption
Translation inhibition
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
60S ribosome
antibiotic
Bacterial
DNA synthesis
NHP2L1, RPL10L, RPL11, RPL13A, RPL15, RPL19, RPL23, RPL23A, RPL26L1, RPL3, RPL37, RPL8, RSL24D1
Parasite
Primary Target
DNA, RNA and Protein Synthesis
MOA
Inhibitor
protein synthesis inhibitor
Cellular injury category
Miscellaneous
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Microbiology/virology
Anti-infection
Source data
