General
Preferred name
CTS-1027
Synonyms
Ro 1130830 ()
RS 130830 ()
CTS 1027 ()
RS-130830 ()
transplant therapy, Conatus Pharmaceuticals ()
RO-1130830 ()
P&D ID
PD004353
CAS
193022-04-7
Tags
available
drug candidate
Drug indication
Hepatitis C virus infection
Drug Status
investigational
experimental
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CTS-1027 inhibits individual members of the MMP family that are believed to be important in inflammation and tissue damage. CTS-1027 was specifically designed, however, not to inhibit MMP 1, as inhibition of MMP 1 was believed to be associated with musculoskeletal side effects.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Pandemic Response Box
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
425.07
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
3.21
TPSA
101.93
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
MMP-12 (Macrophage Elastase) Inhibitors
MMP-13 (Collagenase 3) Inhibitors
MMP-14 (Membrane-Type Matrix Metalloproteinase 1) Inhibitors
MMP-2 (Gelatinase A) Inhibitors
MMP-3 (Stromelysin 1) Inhibitors
MMP-8 (Neutrophil Collagenase) Inhibitors
MMP-9 (Gelatinase B) Inhibitors
"MMP-12 (Macrophage Elastase) Inhibitors
MMP-9 (Gelatinase B) Inhibitors"
metalloproteinase inhibitor
Target
MMP1, MMP13, MMP2, MMP3, MMP9
MMP
Pathway
Metabolic Enzyme/Protease
Source data
