General
Preferred name
A-674563
Synonyms
A674563 ()
A-674563 (hydrochloride) ()
A-674563 HCl (552325-73-2(free base)) ()
A-674563 2HCl(552325-73-2(fb-2hcl)) ()
P&D ID
PD004321
CAS
552325-73-2
2070009-66-2
Tags
available
drug candidate
obsolete probe
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
A-674563 is an inhibitor of the protein kinase B family member, AKT1 .
(GtoPdb)
DESCRIPTION
A-674563 is an orally active Akt1 inhibitor with a Ki of 11 nM.
DESCRIPTION
A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
PRICE
25
PRICE
188
PRICE
182
DESCRIPTION
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1].
(TargetMol Bioactive Compound Library)
DESCRIPTION
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
(TargetMol Bioactive Compound Library)
DESCRIPTION
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
1
Compound Sets
15
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
Kinase Inhibitors (best-in-class)
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
Novartis Chemogenetic Library (NIBR MoA Box)
Obsolete Compounds
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
358.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
3.88
TPSA
76.82
Fraction CSP3
0.18
Chiral centers
1.0
Largest ring
6.0
QED
0.55
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
AKT1
CDK2
ERK2
PKA
PKCδ
Akt
GSK-3β
AKT1, PKIA, PRKACA
Akt,CDK,PKA
Known off targets
PKA, CDK2
Kinase group
AGC
MOA
AKT
CDK
cAMP-Dependent Protein Kinase (PKA) Inhibitors
Inhibitors of Signal Transduction Pathways
PKB alpha/Akt1 Inhibitors
Akt inhibitor
Pathway
GPCR/G protein
Cell Cycle/Checkpoint
Chromatin/Epigenetic
Cytoskeletal Signaling
MAPK
PI3K/Akt/mTOR signaling
Tyrosine Kinase/Adaptors
Stem Cells
PI3K/Akt/mTOR
Member status
member
Source data
