General
Preferred name
SU 5402
Synonyms
SU5402 ()
SU-5402 ()
3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE ()
Sugen SU5402 (3-(hetero)arylmethylidene-2-indolinone derivative) ()
P&D ID
PD004312
CAS
215543-92-3
Tags
available
drug candidate
Drug indication
Multiple myeloma
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SU5402 is an inhibitor of the enzymatic activity of receptor tyrosine kinases, including kinase insert domain receptor (VEGFR-2), fibroblast growth factor receptor 1 (FGFR1) and platelet derived growth factor receptor beta (PDGFRβ) .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
10
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
296.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
2.83
TPSA
82.19
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Angiogenesis
Tyrosine Kinase/Adaptors
Chromatin/Epigenetic
Protein Tyrosine Kinase/RTK
Target
FGFR1
PDGFR??
VEGFR2
PDGFR¦Â
FGFR
PDGFR
VEGFR
MOA
FGFR inhibitor
PDGFR inhibitor
VEGFR inhibitor
Source data
